4,24–26 ACE2 is expressed predominantly in vascular endothelial cells of the heart and kidney
The ARB losartan was found to improve lung injury in mice by reducing levels of Ang II
2), despite similar reductions in blood pressure (11, 22) Plasma and cardiac tissue contents of Ang-(1–7) paralleled the increase in ACE2 activity following losartan treatment in the Lewis rats
ANG II downregulates ACE2 mRNA in neonatal cardiac myocytes and fibroblasts
300mg
Both ACE2 activator drugs, diminazene and losartan reversed all OA behavioral, radiological and histopathological anomalies, together with a decline in knee inflammation and oxidative stress markers
Several hypotheses have been proposed to date regarding the net effect of ACEI/ARB on COVID-19 infections
Next, we determined whether depletion of AGT, the unique substrate of the RAS, changes ACE2
Losartan alone had no statistically significant impact on ACE2 and LRP2 colocalization (ANOVA Tukey post hoc test, vehicle vs losartan, p = 1
Interestingly, during the revision of this manuscript, Zhang et al
Further, losartan also significantly increases cardiac ACE2 activity [5]
Question What is the effect of losartan on lung injury in hospitalized patients with COVID-19?