November 1, 2022
Indications
Azathioprine has been reported to cause temporary depression in spermatogenesis and reduction in sperm viability and sperm count in mice at doses 10 times the human therapeutic dose; 1 a reduced percentage of fertile matings occurred when animals received 5 mg/kg
Call your doctor for medical advice about side effects
When a reprotoxic treatment cannot be stopped and/or when the impact on semen parameters/sperm DNA is potentially irreversible (Sulfasalazine Azathioprine, Mycophenolate mofetil and Methotrexate), the Background
Effect on Sperm in Animals: Azathioprine has been reported to cause temporary depression in spermatogenesis and reduction in sperm viability and sperm count in mice at doses 10 times the human therapeutic dose; 1 a reduced percentage of fertile matings occurred when animals received 5 mg/kg
Although several clinical studies have indicated their safety in both reproduction and pregnancy, in
Details of AZA treatment and concomitant therapy are shown in Table 1
The thiopurine drugs azathioprine (AZA) and 6-mercaptopurine (MP) are widely used for maintenance of clinical remission in steroid-dependent inflammatory for 51 days did not affect sperm morphology or sperm production
Azathioprine does not affect sperm quality or male fertility
Background & Aims: Long-term treatment with azathioprine (AZA) is well established in inflammatory bowel disease (IBD)
The brand name of 6-MP is Purinethol®
Effect on Sperm in Animals: Azathioprine has been reported to cause temporary depression in spermatogenesis and reduction in sperm viability and sperm count in mice at doses 10 times the human therapeutic dose; 1 a reduced percentage of fertile matings occurred when animals received 5 mg/kg
nausea (severe) pains in the stomach, side, or abdomen, possibly radiating to the back
Effect on Sperm in Animals: AZASAN has been reported to cause temporary depression in spermatogenesis and reduction in sperm viability and sperm count in mice at doses 10 times the human therapeutic dose; Azathioprine should not be used in pregnancy without careful assessment of the risks and benefits
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