Ketoconazole, an antifungal antibiotic, inhibits cholesterol synthesis by blocking demethylation of lanosterol
, of
This enzyme is responsible for inhibiting the biosynthesis of triglycerides and phospholipids by fungi
In
Ketoconazole inhibits the biosynthesis of fungal ergosterol and is capable
Dosage
Measurements of circulating precursors of T suggest that ketoconazole may inhibit 17,20
Ketoconazole foam or gel is used to treat seborrheic dermatitis (scaly areas on your skin or scalp)
6 mg/kg orally once a day
Get emergency medical help if you have signs of an allergic reaction (hives, fever, chest pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling)
painful or difficult urination
M
Five patients were treated in a short-term manner (1000 mg over 24 h) and nine patients
By administering 400 mg ketoconazole orally, every 8 hr, serum testosterone levels in or close to the castrate range were obtained within 1 day in prostate cancer Ketoconazole, an antifungal agent, has been shown to lower serum testosterone (T) in man
Oleskan ketoconazole krim ke area bermasalah sebanyak 1–2 kali sehari, selama 2–4 minggu
Overview
The activity of 3 beta-hydroxysteroid dehydrogenase/isomerase (3 beta-HSD), 17-hydroxylase (17-OHase), 17,20-desmolase (17,20D), 17-ketosteroid reductase (17-KSR)
The observation in a few patients that gynecomastia developed during an antifungal therapy with 200 mg ketoconazole daily set the stage for a totally new application for this drug