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Jun 26, 2018 · Sporanox is an antifungal agent and is considered "broad-spectrum", meaning it can be effective for: Dermatophytes (a specific group of pathogenic fungi) Nondermatophytic fungus
Clinical Significance
This test is indicated in patients with life-threatening fungal infections and in patients considered at risk for poor absorption or rapid clearance
Itraconazole therapeutic efficacy is greatest when serum concentrations exceed 0
Its activity results from inhibition of fungal synthesis of
1
This test is used to determine the susceptibility of yeast isolates to antifungal agents
Itraconazole (it" ra kon' a zole) is a synthetic triazole fungicidal agent which acts by inhibition of fungal C14-a- ergosterol demethylase, which leads to a decrease in ergosterol synthesis, a
5 mcg/mL (localized infection) >1 mcg/mL (systemic infection) Hydroxyitraconazole: No therapeutic range established; activity and
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These tests check a sample of the matter that's discharged while coughing (sputum) for the presence of coccidioides organisms
The serum concentration must be interpreted in
If you still have symptoms of infection after you finish the itraconazole, call itraconazole (itra, uplc/ms) cpt 80189 Itraconazole levels are assayed by UPLC/MS technology with both the parent compound and its largest metabolite (hydroxy-itraconazole) being reported
The supernatant is removed and analyzed by an in-house developed liquid chromatography-tandem mass spectrometry method
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Clinical Use
You may need frequent medical tests
Patients with life-threatening fungal infections
Test Name Ordering Code Result Code Component Name LOINC Code AOE Prompt Units; Itraconazole, LC-MS/MS, Serum: 3351620: 3351630:
Age older than 60 years is an Test Code ITCON Itraconazole, Serum Reporting Name Itraconazole, S Useful For
In the itraconazole package insert liver function tests are recommended for patients receiving continuous itraconazole for periods of time exceeding 1 month
Most laboratories test this using HPLC (high performance liquid chromatography) which reports both the itraconazole concentration and the hydroxy-itraconazole concentration
LIS Dept Code Sendouts Mayo Lab (FZ) (MAFZ) Performing Location(s) Test Name: ITRACONAZOLE LEVEL General Information Lab Order Codes: ITRZ Synonyms: (Test# 81247/ITCON) Phone Numbers: MIN Lab: 612 -813 6280 STP Lab: 651-220-6550 Test Availability: Daily, 24 hours Turnaround Time: 1 - 3 days, days test set up varies Special Instructions: N/A Specimen Clinical services
Cerner Order Name: Itraconazole,S-Mayo