Effect of metal ion chelation on in vitro minimum inhibitory concentrations of tigecycline and tetracycline
2019
More recently, biologic actions affecting inflammation, proteolysis, angiogenesis, apoptosis, metal chelation, ionophoresis, and bone metabolism have been researched
The complexation reactions between Fe3+,Cu2+ and Pd2+ ions with tetracycline HCl (TC) in water or DMF were studied by the spectrophotometric methods at [(15, 25, 35 and 45
Part 3
Formation of zinc complexes with tetracycline and some of its derivatives and assessment of their biological significance
EDTA was first used in the 1950s for the treatment of heavy metal poisoning
This finding supports the contention that certain metal ions critically facilitate tetracycline uptake and leads us to suggest possible molecular mechanisms for tetracycline resistance
The acidic functions of the tetracyclines are capable of forming salts through chelation with metal ions
In dairy animals, limits on residues secreted in milk are strictly controlled by legislation
Tetracyclines are removed from these columns with EDTA-containing buffer, and extracts are further cleaned by ultrafiltration
According to this study, this chelating ability explains at least in part their antibiotic activity
Metal chelate compounds with tetracycline derivatives
More recently, biologic actions affecting inflammation, proteolysis, angiogenesis